“Nano Comes to Life”: DNA NanoTech, Medicine and the Future of Biology with Professor Sonia Contera

Nano Comes to Like on Bridging the Gaps

Nanotechnology allows scientists to better understand, interact with, and manipulate biology by creating and manufacturing artificial structures and even machines at the nanoscale out of DNA, proteins, and other biological molecules. From nanoscale machines that can target individual cancer cells and deliver drugs more effectively to nanoantibiotics that can fight resistant bacteria, to the engineering of tissues and organs for research, drug discovery, and transplantation, nanotechnology is revolutionizing medicine in ways that will have profound effects on our health and longevity.

In this episode of Bridging the Gaps I speak with Professor Sonia Contera and we discuss fascinating research that she presents in her book “Nano Comes to Life: How Nanotechnology Is Transforming Medicine and the Future of Biology”. The book introduces readers to nanotechnologies, which are fast advancing and allowing us to influence the basic building components of life. Sonia Contera provides an insider’s view of this new frontier, explaining how nanotechnology permits a new sort of transdisciplinary science that has the potential to give us power over our own biology, health, and lifestyles. Sonia Contera is professor of biological physics in the Department of Physics at the University of Oxford. Her work lies at the interface of physics, biology, and nanotechnology, with a particular focus on the role of mechanics in biology.

We start by discussing the scale at which nanotechnologies function. The evolution of instruments and technology that allow us to perceive and interact with matter on such a microscopic scale is then discussed. The convergence of numerous sciences that are at the heart of such breakthroughs are then discussed, allowing us to build nano-scale structures from the ground up. We then discuss the fascinating research that enables researchers to design proteins on a computer simulator, figure out what kind of GENOME will make such protein from that simulated protein, create that GENOME, and then put it in a real cell to create that protein in reality. We also touch upon the cutting edge research in DNA Nanotechnology and other enabling technologies such as Artificial Intelligence, and the future of biology and medicine. This has been a fascinating discussion.

Complement this discussion by listening to “Artificial Intelligence: Fascinating Opportunities and Emerging Challenges with Professor Bart Selman and then listen to Is Philosophy Dead? On the Bittersweet Relationship Between Science and Philosophy” with Professor Tim Maudlin.

“Free Will” Through the Lenses of Philosophy and Neuroscience with Dr Alfred Mele

"Surrounding Free Will"

The debate over whether or not free will exists is not new. The main points of contention in this discussion are whether or not we have control over our actions, and if so, what kind of control we have and to what extent. On the one hand, we have a strong sense of liberty, which causes us to trust in our own free will. An intuitive and instinctive sense of free will, on the other hand, could be misinterpreted. In this episode of Bridging the Gaps, I speak with Dr Aflred Mele and we discuss the concept of “Free Will” from the perspective of philosophy and from the perspective of neuroscience.

Dr Alfred Mele is a Professor of Philosophy at Florida State University. His research interests include issues about human behavior located at the intersection of philosophy and science such as free will, personal autonomy, self-deception, self-control, intention, intentional action, motivation, and moral responsibility. He is also the past Director of the Philosophy and Science of Self-Control Project and the Big Questions in Free Will Project.

I open this discussion by asking Dr Mele to unpack the concept of “Free Will”. I then ask Dr Mele to outline important philosophical views about the concept of “Free Will” that emerged over time. We discuss in detail the relevant concepts of determinism, compatibilism, incompatibilism, and libertarianism. We then discuss the concept of Free Will through the lens of neuroscience. We discuss a number of experiments conducted by neuroscientists. The finding of these experiments seems to suggest that that free will is an illusion. But the question is, is it right to extrapolate the findings of these experiments that focus on simple choices and are conducted in controlled environments to conclusively suggest that free will does not exist. Dr Mele discusses this point in detail.

Complement this conversion with fascinating discussion with Professor Renata Salecl on “A Passion of Ignorance and Denials” and then listen to Professor David Chalmers in: “From Consciousness to Synthetic Consciousness”.

By |July 25th, 2021|Neuroscience, Philosophy, Podcasts, Research|

The Spike: Journey of Electric Signals in Brain from Perception to Action with Professor Mark Humphries

Neurons are the fundamental building blocks of the brain. In the human brain, billions of these neurons communicate and liaise with one another using spikes, blips of electric voltages. Studying and understanding how these spikes emerge in the brain, how they travel through the brain and how this communication leads to meaningful actions are part of the cutting edge research in the field of neuroscience. In this episode of Bridging the Gaps I speak with professor Mark Humphries and discuss the research that he presents in his new book “The Spike: An Epic Journey Through The Brain in 2.1 Seconds”. This is a deeply informative account of the journey that these electrical signals take as they move from one neuron to another and eventually lead us to act. The book tackles previously unanswered mysteries: Why are most neurons silent? What causes neurons to fire spikes spontaneously, without input from other neurons or the outside world? Why do most spikes fail to reach any destination? In this thorough discussion with professor Mark Humphries, we touch upon these fascinating questions and intriguing concepts.

Mark Humphries is Chair in Computational Neuroscience at the University of Nottingham. He is the founding editor of “the Spike” an online publication available at Medium dot com.

I begin our conversation by asking Mark about the structure of an individual neuron and how spikes emerge in a single neuron. We then discuss the concept of Dark Neuron and talk about the spikes that don’t lead to new spikes and just fail. A very interesting question is what do these spikes mean and how do these spikes carry messages from one point in the brain to another. In the book, Mark reports two groups of researchers holding two different viewpoints, these are “The Timers” and “The Counters”. I ask Mark “who are the timers” and “who are the counters” and what are their viewpoints on the question that how these spikes carry messages from one point in the nervous system to another. And finally we discuss how research is conducted in the fields of neuroscience and computational neuroscience. We particularly discuss progress that the researchers are making in the field of computing neuroscience.

Complement this podcast with the fascinating discussion with Professor David Badre “On Task: How Our Brain Gets Things Done” and then listen to Professor Daniel Schacter on “Seven Sins of Memory”

By |June 7th, 2021|Neuroscience, Podcasts, Research|