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Evolution is often described as a process of constant improvement. Yet many features of human biology challenge this assumption. Genetic diseases remain common. Large parts of our DNA appear to serve no clear purpose. Pregnancy is also highly inefficient, and many fertilised eggs do not survive.
These apparent flaws raise wider questions about how evolution works. Are they failures of natural selection, or are they predictable outcomes of evolutionary processes? What role do pregnancy, population size, mutation, and chance play in shaping the human genome?
In his book, “The Evolution of Imperfection: The Science of Why We Aren’t and Can’t Be Perfect” evolutionary geneticist Laurence Hurst examines these questions. He explores how genetic medicine may reduce the effects of these inherited weaknesses. By examining the apparent failures of evolution, the book offers a deeper account of natural selection and a richer understanding of what it means to be human. In this episode of Bridging the Gaps, I speak with Professor Laurence Hurst.
Laurence Hurst is professor of evolutionary genetics in the Milner Centre for Evolution at the University of Bath. His research on how genetic systems evolve, and the application of this knowledge to medicine, has been recognized with national and international prizes and fellowships.
We begin by discussing several evolutionary imperfections examined in the book. I then ask Laurence to explain what DNA is and how it contributes to evolution. His explanation provides a foundation for the rest of the conversation.
We return to the question of imperfection and examine it through the lens of genetics. We discuss the biological challenges of pregnancy and the complex interaction between the embryo and the mother. Laurence explains why some of these processes appear counterintuitive. We also discuss the role of chance in shaping evolutionary outcomes.
The conversation also explores so-called “junk DNA,” the sections of the genome whose functions remain unclear. We then turn to emerging technologies, including gene therapy and CRISPR. We consider how fair and equal access to these tools could help address genetic diseases and inherited imperfections.
The discussion offers an insightful exploration of several complex ideas in evolution, genetics, and modern medicine.
Complement this discussion with “The Evolution of Biological Information: How Evolution Creates Complexity, from Viruses to Brains” with Professor Christoph Adami and then listen to “The Network of Life: A New View of Evolution” with Professor David Mindell
The universe may appear chaotic. Yet beneath this apparent disorder lies a vast network of rules. These rules shape patterns of action, force, and consequence. In “Ten Patterns That Explain the Universe”, popular science writer Brian Clegg examines the systems that govern the physical world. He focuses on ten essential patterns that reveal how the universe is structured and how it behaves. The book explores the relationship between space and time, the quantum behaviour of matter and light, and the origins of the cosmos. It explains how the cosmic microwave background, often described as the “echo of the Big Bang,” provides evidence about the early universe. It also shows how the periodic table reflects the underlying structure of atoms. Through clear explanations, detailed illustrations, and informative diagrams, Clegg presents a distinctive view of the universe and its fundamental workings. In this episode of Bridging the Gaps, I speak with Brian Clegg. We also discuss his book “Ten Days in Physics That Shook the World”, which examines pivotal moments when major scientific breakthroughs transformed our understanding of reality and reshaped everyday life.
Brian Clegg is an award-winning popular science writer and the author of more than thirty books.
I begin by asking Brian what inspired him to write popular science books. We then discuss the title of Ten Patterns That Explain the Universe. We explore what constitutes a pattern and how patterns can help us understand the workings of the universe.
Drawing on a question often raised in mathematics, I ask whether these patterns exist independently and are discovered by us, or whether they are created through human interpretation. We then examine several patterns discussed in the book. We begin with the cosmic microwave background, the residual heat left in the universe after the Big Bang.
Brian also includes several diagrams among the patterns presented in the book. I ask why diagrams, which are human-made representations, should be regarded as patterns that explain the universe. We discuss diagrams associated with quantum mechanics and consider what they reveal about events at the quantum level.
The conversation then turns to the patterns found in the periodic table. We consider whether the table could have been organised in other ways. We also discuss the double-helix structure of DNA and examine the many forms of symmetry found in nature. Brian explains why symmetry is his favourite pattern.
We then focus on Brian’s other book, Ten Days in Physics That Shook the World: How Physicists Transformed Everyday Life. I ask which of the ten days he considers the most significant. We also discuss the book’s final example: the establishment of the first internet connection.
The discussion concludes with the challenges created by information overload, misinformation, and disinformation. We consider the importance of public understanding of science and the role of effective science communication. I ask Brian which approaches are most successful, particularly within research and academic institutions. We also examine who should be responsible for communicating scientific findings: the original researchers or specialist science communicators.
Complement this discussion with “Sharing Our Science: How to Write and Speak STEM” with Professor Brandon Brown and then listen to On Public Communication of Science and Technology with Professor Bruce Lewenstein
How does the brain produce consciousness? Why should electrical and chemical activity in the brain give rise to thoughts, emotions, colors, sounds, and the feeling of being alive? Despite major advances in neuroscience, the inner nature of experience remains difficult to explain. Modern science can describe the brain’s physical processes in great detail, but it still struggles to explain why those processes are accompanied by subjective awareness. The book “Galileo’s Error: Foundations for a New Science of Consciousness” by Professor Philip Goff takes this problem as its starting point. Goff argues that the difficulty may lie not simply in our lack of scientific knowledge, but in the way modern science has defined the physical world since Galileo. By separating matter from subjective experience, science became highly successful at explaining the measurable world, but left consciousness outside its basic picture of reality.
To address this, Goff introduces panpsychism: the idea that consciousness, in some very simple form, may be a fundamental feature of matter itself. The book aims to show why this view should be taken seriously and how it might offer a new path toward understanding the relationship between mind, matter, and the universe.
Philip Goff is a philosophy professor at Durham University, UK. He spends most of his time trying to work out the ultimate nature of reality. In this episode of Bridging the Gaps, I speak with Professor Philip Goff.
Our discussion begins with Philip Goff’s central claim in Galileo’s Error: that the scientific paradigm developed over the past five hundred years was designed, from the time of Galileo, to exclude consciousness from its picture of the physical world. We explore what this means, why Goff regards this exclusion as a mistake, and how it shaped the modern scientific worldview.
From there, the conversation examines how this Galilean paradigm differed from earlier ways of understanding nature, and how it contributed to a materialist view of consciousness: the idea that consciousness is simply an emergent product of physical processes in the brain. We consider what may be missing from this account and why it struggles to address the so-called “hard problem of consciousness”—the question of why and how physical processes give rise to subjective experience.
The discussion then turns to the contrast between the mathematical description of the world provided by science and the rich inner life of conscious beings. We consider Goff’s argument that science gives us an incomplete picture of reality because it describes matter from the outside while leaving out its intrinsic nature. This leads to the possibility that the hidden, intrinsic nature of matter may help explain human and animal consciousness.
A central part of the conversation focuses on panpsychism, the view that mind or consciousness is a fundamental feature of the world and may exist, in some basic form, throughout the universe. We explore what this means, whether it implies that the universe itself is conscious, and how this approach reframes the hard problem of consciousness. Finally, the discussion considers deeper questions about the fundamental nature of reality, including whether information may lie at its foundation, before concluding with reflections on the provocative title of the book, Galileo’s Error.
Complement this discussion by listening to From Consciousness to Synthetic Consciousness: From One Unknown to Another Unknown with David Chalmers followed by “The Case Against Reality” and The Hard Problem of Consciousness with Professor Donald Hoffman and Why You Are Not Your Brain? A Conversation on Consciousness with Alva Noe, Ph.D..
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